The Luscombe Lab
in London and Okinawa

NGS data analysis workshop

We are co-organising a hands-on workshop for NGS data analysis in Okinawa, Japan (6-10 October 2014). This workshop aims to familiarize participants with the analysis of high-throughput sequencing (HTS) data and provide hands-on training on the latest analytical approaches. The course consists of a well balanced mixture of lectures, giving insight into how to analyze HTS data, and practicals, consisting of computational exercises that will enable participants to apply statistical methods to the analysis of RNA-seq and ChIP-seq data, under the guidance of the lecturers and teaching assistants. More information at:

Bioinformatics Faculty Postion at Crick!

Here is a fantastic opportunity for computational research at the London Research Institute and Francis Crick Institute! The LRI, which will join the Crick Institute in 2015, has opened a faculty position dedicated to computational work, including areas such as bioinformatics, genomics, mathematical modelling and image analysis. Positions are extremely well funded, and it is an exciting place to work right in the heart of London.

Here is the job website. Applications close on 22 November 2013. Do contact me if you have any questions!

Intel-Crick workshop underway


The Intel-Crick workshop “Computational challenges and performance optimizations in NGS data analyses” starts today! It’s taken a lot of conference calls to pull it together and I think we have put together a very interesting and exciting program.

A lot of thanks go to Robert Maskell, Kristina Kermanschahche and Clay Breshears from Intel; Gabriella Rustici (Brazma Group, EBI), Robert Sugar and Kathi Zarnack from the Luscombe lab for all their hard work.

Garth's paper published in eLife

Garth is a staff scientist in our Okinawa laboratory, and he has just published a paper modelling gene expression in the developing fly embryo. It is accompanied by a Preview by Mike Levine.

He applied a logistic regression model that reproduces eve expression very accurately; in fact the models work so well that they even predict perturbations such as regulator knockouts and mis-expression. The image shows the predicted expression of eve 2 in (a) wild-type and (b) gt mutant embryos.

This is the result of several long-standing collaborations, particularly Angela DePace. Congratulations to Garth on this elegant paper!

New from Aswin


Aswin Sehsasayee is a former PhD student who now runs his own research group at the National Centre for Biological Sciences in Bangalore India. He has just been elected as an Associate of the Indian Academy of Sciences, an honour awarded to a few scientists under the age of 35. Congratulations to Aswin!

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